What is Sinemet? What are the therapeutic benefits of Sinemet?
Sinemet is very effective in managing symptoms allied with Parkinson disease and parkinsonism-like symptoms caused by other conditions such as shakiness, stiffness or difficulty in moving. Parkinson disease occurs due to deficiency of naturally occurring neurotransmitter called dopamine in the brain. Sinemet is an antidyskinetic combination of Levodopa and Carbidopa.
What is the exact working of Sinemet?
Levodopa is the metabolic precursor of Dopamine; it crosses the blood brain barrier and gets transformed in the brain into a substance called Dopamine that helps to decrease tremors and other symptoms of Parkinson disease. Carbidopa inhibits the breakdown of Levodopa in the bloodstream so more Levodopa can enter the brain.
What is the correct dosing regimen of Sinemet?
Sinemet tablet is commercially available in 1:4 ratio of Carbidopa to Levodopa (Sinemet 25-100) as well as 1:10 ratio (Sinemet 25-250 and Sinemet 10-100).
Initial dosing regimen: Initially, a patient has to consume one tablet of Sinemet 25-100 orally thrice a day. A patient can enhance the dose by one tablet every day or every other day, as required, until a dosage of eight tablets of SINEMET 25-100 a day is reached. If a patient is previously taking Levodopa, then Levodopa must be discontinued at least twelve hours before starting Sinemet.
Maintenance dosing regimen: The dose should be adjusted according to the desired therapeutic response. At least 70 to 100mg of Carbidopa is required in a day. When greater amount of Carbidopa is required, then a patient can substitute one tablet of Sinemet 25-100 for each tablet of Sinemet 10-100. When high amount of Levodopa is required, then a patient can substitute one tablet of 25-250 Sinemet should be substituted for Sinemet 25-100 or Sinemet 10-100.
Under what conditions the use of Sinemet is contraindicated?
- Sinemet is contraindicated, if a patient suffers from narrow-angle glaucoma.
- It should not be used by a patient with suspicious, undiagnosed skin lesions or a history of melanoma.
- If a patient is hypersensitive to this medicine or its other components, then avoid the use of this medicine.
- If a patient had used a monoamine oxidase inhibitor within the last 14 days, then avoid using this medicine.
What are the safety measures to follow by a patient while using Sinemet?
- It may cause drowsiness or dizziness, so it is advised not to drive a vehicle or operate any machinery.
- It is advised avoid the use of this medicine in case of hot weather, exercise, or fever.
- Avoid the ingestion of alcoholic beverages along with these medicines.
- Diabetic patients, pregnant ladies and breastfeeding mothers are advised to consult the doctor before using this medicine.
What are the side effects of Sinemet?
A patient who is using Sinemet may come across some side effects such as abnormal dreams, constipation, lightheadedness, abdominal pain, sleepiness, dry mouth, headache, nausea, trouble sleeping, vomiting and shortness of breath
What are the possible drug interactions of Sinemet?
There are some medicines that show interactions with Sinemet such as Phenelzine, Amitriptyline, Metoclopramide, Rasagiline, Selegiline, Haloperidol, Isoniazid, Papaverine, Chlorpromazine, Phenytoin, Reserpine and Risperidone